What is malaria?

A parasite called Plasmodium causes malaria. A bite from an infected mosquito passes the parasite to humans. These mosquitoes are found in the tropics and subtropics in almost all countries. Nearly all cases of malaria in the U.S. occur in people who have traveled to other countries. Treatment removes the parasite from the blood.

After the parasites get into the body by a mosquito bite, they gather in the liver. After several days, infected red blood cells (RBCs) emerge from the liver. The parasites from these cells infect other RBCs.

If you are bitten by a Plasmodium-infected Anopheles mosquito, you can get malaria. Several different species of Plasmodium can infect mosquitoes. Some species cause more serious problems than others do. One species in particular (Plasmodium falciparum) can be life-threatening. It may cause liver and kidney failure along with shock. Two other species of Plasmodia can stay inactive (dormant) in the liver for many months or years, but then reactivate. Another species can stay alive in the body for many years, causing a long-term (chronic) low-level infection.

Who is at risk for malaria?

The risk of getting malaria depends on:

• Your travel destination
• How long your trip is
• Places where you will spend the evenings and nights. Anopheles mosquitoes bite most often during nighttime hours from dusk to dawn.

Malaria Symptoms

Early stages of malaria may be like the flu. These are the most common symptoms of malaria:

• Fever
• Chills or sweats
• Headaches
• Muscle ache
• Extreme tiredness (fatigue)
• Upset stomach (nausea)
• Ill feeling (malaise)
• Sometimes vomiting, diarrhea, and coughing

Symptoms of malaria often start from 7 to 30 days after the mosquito bite. Or it can develop as late as several months or years after leaving a place where there is malaria.

Always talk with your healthcare provider for a diagnosis.

Malaria Diagnosis

Your healthcare provider will ask about your past health and travel history and do a physical exam. You may also have blood tests to rule out other possible infections. Using a microscope and other types of testing, your provider can confirm if you have malaria parasites in your blood.

Malaria Treatment

Treatment will depend on your symptoms, age, and general health. It will also depend on how severe the condition is.

Treatment in the early stages works best. Delaying treatment can lead to serious problems. Treatment for malaria will vary depending on which species of Plasmodium you were infected with.

Treatment may include:

• Antibiotics. These medicines kill the parasite in the blood.
• Supportive care. You may need medicines such as acetaminophen for fever and IV (intravenous) fluids if there are complications.

What are possible complications of Malaria?

Complications of malaria are more common with falciparum malaria. It's the most potentially life-threatening type of the disease. People with a severe case of this type may have:

• Liver and kidney failure
• Ruptured spleen
• Convulsions
• Shock
• Coma
• Ill effects on the baby if the infected person is pregnant
• Death

Malaria Prevention

You can prevent malaria by using antimalarial medicines when you may be exposed to the disease. Also take measures against mosquito bites. These include using mosquito nets when sleeping at night and insect repellent during the day.

The World Health Organization has approved a malaria vaccine for use in children living in areas of the world at high risk for malaria. Over the next few years, this vaccine will be increasingly offered to children who are at the highest risk. Other malaria vaccines are in development.

Malaria Medications

When planning to travel to a place where malaria occurs, talk with your healthcare provider well before your trip. They can give you medicine to prevent malaria. But travelers to different countries may be given different advice. Travelers visiting cities or rural areas where there is no risk of getting malaria may not need preventive medicines. Give your provider an exact list of the places you will be. Your provider can then decide what treatment you need.

Several medicines can prevent malaria in travelers. Deciding which medicine is best depends on several factors. These include:

• The type of malaria that is common where you are going
• Your health history
• The amount of time you have before your trip

For treatment to work, you must take the medicine exactly as prescribed. You must start these medicines before you arrive at your destination. And you must continue them for a certain number of days or weeks after your return. The time period depends on which medicine is prescribed.

Mosquito Prevention and Malaria

You are still at risk for malaria even when using protection.

To prevent mosquito bites, the CDC advises you:

• Use insect repellent on exposed skin. Choose repellent that has greater than or equal to 20% N,N-diethyl-meta-toluamide (DEET). Repellents used on a child should contain no more than 30% DEET.
• Wear long-sleeved clothing and long pants if you are outdoors at night.
• Use a mosquito net over the bed if your bedroom is not air-conditioned or screened. For more protection, treat the mosquito net with the insecticide permethrin.
• Spray an insecticide or repellent on clothing. Mosquitoes may bite through thin clothing.
• Spray pyrethrin or a similar insecticide in your bedroom before going to bed.

Vitamin B and ultrasound devices don't prevent mosquito bites. You can find important, current information about prevention and precautions at www.cdc.gov/malaria.

When should I call my healthcare provider?

If you become ill with a fever during or after travel in a malaria risk area, get medical care right away. Tell your healthcare providers of your recent travel. Don’t assume you have the flu or some other disease without having a lab test to find out if the symptoms are caused by malaria.